Formulation and Evaluation of Sustained Release Microcapsule of Metronidazole

نویسندگان

چکیده

The oral conventional metronidazole dosage forms have a short duration of action due to gastric emptying process, hence the treatment ulcus pepticum using become less effective. Due retaining form in stomach, preparation sustained released drug delivery systems has been developed. aim this study was developed alginate and chitosan as polymers that could last longer stomach. formulation consisted variatons 0.5%, 0.75% 1%. test carried out paddle method simulated medium pH 1.2 at 37°C. dissolution results showed formula with giving best effect kinetics realeased microcapsule followed Higuchi order. Based on study, it can be concluded microcapsules combination prepared formulation.

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ژورنال

عنوان ژورنال: International Journal Of Science, Technology & Management

سال: 2022

ISSN: ['2722-4015']

DOI: https://doi.org/10.46729/ijstm.v3i6.643